Cole, who was diagnosed with Hepatitis C in April 2008 and treated the liver disease with chemotherapy, also battled kidney problems later that year.

"You know, things don't always go the way we want it to," she said at Wednesday's concert, where she sang 17 songs – including fan favorites "This Will Be," "Our Love," and "Unforgettable" – and even danced along to a few tunes. "Things happen unexpectedly. You got to take the good with the bad."

Looking back at the past few months, which she described as "a real tough journey," and seeing how much she's recovered, Cole says her next goal is to bring awareness to the health problems she's overcome.

"One in eight people has kidney failure," she said. "That's a lot of people and I never thought it would happen to me, but here we are."