Will Smith leads the pack of Hollywood's best-paid actors, banking an estimated $80 million over the course of the year. Frequently called the hardest-working man in Hollywood, Smith has proved that no matter the genre -- be it sci-fi thriller ("I Am Legend") or sappy drama ("The Pursuit of Happyness") -- he can deliver an audience.

The former "Fresh Prince of Bel Air" star also set a theatrical record this year. Thanks to the commercial success of this summer's anti-superhero flick "Hancock," Smith is the first actor in Hollywood history to have eight straight movies eclipse $100 million at the box office.

Coming in second on the list is "Pirates of the Caribbean" star Johnny Depp, who earned $72 million in the same period. With earnings of $55 million each, Eddie Murphy and Mike Myers tied for third place. Leonardo DiCaprio rounds out the top five, raking in $45 million.

Wondering which gals make the most dough? Cameron Diaz is the best compensated, taking home $50 million. Keira Knightley is next with $32 million, followed by Jennifer Aniston with $27 million.

No surprise here: Oprah Winfrey was the highest-earning media personality, earning $275 million.

Among TV stars, "Two and a Half Men" actor Charlie Sheen pulled $20 million to be the highest-paid man and "Grey's Anatomy" actress Katherine Heigl topped the ladies with $13 million.